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FIGURES B1-B5
These pictures are of a specimen obtained about one year later of the same lesion depicted in figures A1-A5. The current specimen shows evidence of progressive neoplasia. The lesion in this specimen is pandermal and involves margins of resection.
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The lesion is more cellular at this time, and fascicular patterns at the dermal-epidermal interface are more prominent.
fig. B1
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Cytologic atypia is marked, and there is an occasional mitotic figure. High power of above.
fig. B2
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fig. B3
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The fascicular patterns in figures B1, B2 and B3 add a new dimension to the pathology.They have neuroid qualities and are of a type which often anticipates the appearance of a neurotropic component. The lavender cytoplasm of the neoplastic cells is often a feature of desmoplastic and neurotropic melanomas in the late stages of their evolution.
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Atypical spindle and stellate cells are individually isolated among collagen bundles. The pattern of the collagen bundles shows increased complexity. Tissue mucin is slightly increased.
fig. B4
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Tumor cells are immunoreactive for S-100. The HMB-45 reaction was negative.
fig. B5
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