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FIGURES C1-C4
The last in the sequential series of specimens of the lesion previously depicted in figures A1-A5 and B1-B5 is presented here. Figures C1 and C2 are from skin. Figures C3 and C4 are from a nodal metastasis.
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In the dermal component, atypical spindle cells are individually isolated and are loosely arranged in polarized patterns among thin collagen bundles. The pattern of collagen bundles in the dermis is altered.
fig. C1
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Skin
fig. C2
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In the field shown above, the lesion has acquired epithelioid qualities in that cell to cell contact is represented and clustered cells form interlacing fascicles. These epithelioid patterns (clusters of cells in back to back arrangements) provide a neuroid quality even in the absence of neurotropic components. They resemble patterns often seen in malignant epithelioid schwannomas.
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In this nodal metastasis, the epithelioid qualities are both cellular (round cells) and communal (clusters of cells).
fig. C3
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Focally in the nodal metastasis, the thin fasciculated patterns have a neuroid quality and a delicate, inflamed stroma supports the fascicles. The patterns are neuroid.
fig. C4
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