Ch12 Basement Membrane

F1Ch10 (112942): The epidermis shows hypergranulosis. Individual cells in both the superficial and basal units show dyskeratosis; even occasional basal cells show increased cytoplasmic acidophilia. Some of the keratinocytes that are dyskeratotic also show perinuclear vacuoles. Focally, the basement membrane is coarsened and hyalinized; there are areas of liquefaction degeneration. Much of the fibrous component, from the center of the field to the right, has the qualities of reduplicated basement membrane material. Some to the cells in the dermis near the D-E interface are encircled by this material. The material focally loops about one or several cells at the D-E interface. Many of the cells appear to be histiocytes. In essence, the pattern is a variation of changes seen in a lichenoid reaction. There are scattered dendritic cells but it is difficult to identify a convincing melanocyte.


Buster (the plight of feral cats)

F2Ch10 (112942): The basement membrane is extremely variable in distribution and outline. In areas, the basement membrane is coarsened and hyalinized. An occasional cell at the D-E interface has the features of a melanocyte. Fiber patterns in the dermis, near the D-E interface are interpreted as evidence of reduplication of basement membrane. Occasional loops of basement membrane material project from the basement membrane zone into the dermis. One or more cells are enclosed within the confines of the loops. Melanoderma is a feature. There is one stellate multinucleated giant cell, just to the right of the center of the field. Blue arrows identify dyskeratotic cells; most of the dyskeratotic cells show a peripheral rim of acidophilic cytoplasm.


F3Ch10 (9112942): Focally, there is and increased number of vessels in the dermis. Some of the vessels form small angiomatoid clusters. Some of the vessels show a perivascular deposit of a pale matrix; blue arrows identify one such vessel. For at least one of the vessels, laminated membranes are present outside the pale matrix. The small vein at the bottom of the field - cut in longitudinal section - shows irregular deposits of the pale matrix.


F4Ch10: Several venules are represented in cross-section. Endothelial cells have enlarged nuclei. A pale matrix presses upon the endothelial layer. Blue arrows identify duplicated hyaline membranes at the periphery of the pale deposits. Collagen bundles above the center of the field are coarsened and closely aggregated. Those of the lower 1/2 of the field are loosely spaced.


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