Ch12P4-L3 
    Hair Cycles (the inconstant portion)

Bar below is borrowed from another site. It will be mostly inoperative on this site. It offers a review of material available on another site. To go to other sites click:

1. Histopathology of Inflammation

2. Minimal Deviation Melanoma, etc.

 

Navigation aids below this level have special attributes (as described both below, and in the Image Map)

R4564hairmatrporo261

F1Ch12 (R4564): This section includes only a small portion of the outer surface of the hair bulb. There is a kink in the follicle and the bulb is directed out of the plane of the section (kinks of this type correlate with kinky hair, and are a feature of the hair of Blacks). The outer root sheath is composed of uniform cells that have clear cytoplasm; they are rich in glycogen. The termination of the outer root sheath is represented. The inner root sheath is composed of what is generally characterized as three sheaths - each of the three sheaths (“layers”) has been characterized as representing a distinctive epithelium (but the keratinized product is basically identical for all three). The sheath of the hair shaft, as represented near the center of the field (blue arrows), is partially within the plane of the section. Green arrows identify Henle’s layer; bright red trichohyaline granules identify Huxley’s layer; and yellow arrows identify the “cuticle” of the inner root sheath. Red arrows identify the dark cells of the “cuticle” of the hair shaft - appearing as a file of cells at the level of the section . This terminology is open to criticism, but is accepted without question. The term, cuticle, is most appropriate when the product is hard keratin; a structural cuticle about the cortex of the hair is seen along the hair shaft only after the shaft has separated of the inner root sheath (i.e., at the terminus of the latter).

At the distal extremity of the inner root sheath, as represented in this plane, a cellular sheath (consisting of cells of the “cuticle of the inner root sheath) appears as a solid layer (area defined by 5 blue arrows) in which the nuclei are elongated and thin; in the area defined by the blue arrows, the orientation of the long axis of each of these nuclei appears to be perpendicular to the longitudinal axis of the hair shaft. The bright red cytoplasmic granules of the cells of the    multi-layered zone of the inner root sheath (Huxley’s layer) are trichohyalin granules. The innermost sheath (inner root “cuticle”) is not well defined at this level. The outermost sheath (Henle’s layer)of this layer, being a single cell layer in thickness, appears as a file of small cells with pyknotic nuclei and pale acidophilic cytoplasm; it defines the boundary between the inner and the outer root sheaths. At a higher level, a single row of similar flattened cells (“cuticle” of the inner root sheath) (yellow arrows) separates the sheath of granular cells from a sheath of darker acidophilic cells (“cuticle” of the shaft) that is closely applied to the cortex of the hair shaft. The inner most structure in the above figure is the proximal end of the growing hair shaft (the root). In this area, for this example, the keratinizing cells of the hair root are still nucleated; the long axis of each thin, elongated nucleus is parallel to the long axis of the follicle. A thin layer of loosely cellular, loose fibrous tissue outlines this portion of the follicle. The external hyaline membrane that abuts upon the fibrous sheath is characterized as the vitreous, or glassy membrane.

The above is description differs somewhat from classic characterizations. The inner root sheath should be accepted as a single population of keratinizing cells with keratinization being associated with the formation of trichohyaline granules. The inner and outer layers may not be separate and distinct populations of cells; they may be the expression of terminal differentiation, with the cells of “Huxley’s” layer being the progenitors. The inner root sheath is a population of cells, derived from the population of pale cells of the hair bulb. It grows with the hair shaft as a sleeve but appears on a histologic section as a column; it has a multi-layer core of cells rich in trichohyaline granules; keratinization finds expression in the formation of a single layer of keratinizing cells on the inner and outer surface of the trichohyalin-rich column.

Guide (arrows): red - cuticle of hair shaft (dark cells); yellow - “cuticle” of inner root sheath; green - Henle’s layer; blue - en face representation of dark cells of cuticle of hair shaft.

R4564hairmatrporo320

F2Ch12: Below the level of the sebaceous glands, the patterns of the inconstant porton are those of a resting phase. The epithelium below the sebaceous glands is uniform and, histologically, it is common squamous epithelium. The two sebaceous glands are elongated and hang down in the style of appendages (see F2Ch13P4 for a similar pattern but lacking evidence of sebaceous differentiation).

R4564hairmatrporo490

F3Ch12: In this catagen pattern, the hair shaft has lost continuity with germinative epithelium. The detached hair is irregular at its extremity. Beneath the detached shaft, the epithelium shows disorganized and irregular keratinization. There is an ill-defined interface formed on each side at the site where the wings of what probably was once the outer root sheath abuts upon a self- immolating extremity; the central cluster of catagen-dedicated cells is representative of what was once the hair bulb. A glassy membrane is represented. The pattern of keratinization is important; it serves as a model for patterns of keratinization in proliferating, catagen-dedicated, tricholemmal tumors.

R4564hairmatrporo330

F4Ch12: A common fibrous sheath bifurcates to ensheath two resting follicles. Thin epithelial appendages hang down on either side of the small follicle near the center of the field. This pattern is sometimes cited as evidence of a follicular mantle but probably provides evidence of a participation by sebaceous glands in the cyclic events affecting some hair follicles.

R4564hairmatrporo340

F5Ch12: This resting follicle has irregular outlines. The projections produce a pattern that has been characterized as a mantle.

BuiltWithNOF

 Bars below offer access to web Sites & other topics

 

Two clusters of Navigation bars to the right provide access to other  Sections on this site. 

 UP         DOWN            NEXT            PREVIOUS