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1. Histopathology of Inflammation

2. Minimal Deviation Melanoma, etc.

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F1Ch18 (R4564): The cells cytologically more closely resemble the cells of a hair bulb than those of a common basal cell carcinoma. The cells have matrical qualities. A well-defined fibrous sheath outlines the nests of cells. Focally, there is a symmetrially rounded microcyst that is symmetrially placed in the nests. Focally, in some of the nests, some of the basophilic cells are more tightly clustered to form poorly defined whorls. A portion of the squamous cell component is represented at the right hand margin of the field. There is no continuity between nests of basophilic cells and nests of squamous cells.

F2Ch18: The patterns as seen in F1 are repeated at a higher magnification. A dark whorl of basophilic cells in the small nest below the center of the field is pear-shaped; this configuration suggest the possibility that some of the whorls represent abortive attempts to form hair matrix, or even components of the inner root sheath.

F3Ch18: The cytologic features of the basophilic cells are similar to those seen in primitive hair bulbs. The nest has cavitated centrally. Many of the basophilic cells are pigmented; some of the cells in the pigmented areas must be melanocytes. Pigmented debris has collected in the central lumen. Red arrows point to globular deposits in the stroma adjacent to the nest of tumor cells; these deposits are interpreted as amyloid deposits. They are common in the stroma of seborrheic keratoses, and well-differentiated basal cell carcinomas.

F4Ch18: Laminated fibrous tissue has formed at the extremity of a column of tumor cells. A thin sheath of fibrous tissue outlines this column. Melanin deposits are present within the extremity of the column of tumor cells. The patterns suggest a reaction to regressive changes in this nest of tumor cells. The patterns suggest regressive patterns as might be seen following an abortive attempt to differentiate as a follicular component.

F5Ch18: The tumor cells have matrical qualities. There are ill-defined, small, dark whorls of tumor cells in this nest. Centrally, there are degenerative changes with prominent deposits of melanin.

F6Ch18: There is a mild degree of atypia in the basaloid (germinative) component of this nest of squamous cells. Scattered tumor cells are pigmented. Dendritic cells (blue arrows) are regularly spaced among squamous cells of this expanded basal unit. Some of the cells are interpreted as melanocytes. Others on the basis of size and nuclear features probably represent Langerhans cells. Amyloid deposits are present in the stroma adjacent to the nest of squamous cells.