Ch20P12-L3 Catagen-like Tumor &
Sebaceous Epithelioma

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F1Ch20 (G8391): This field is representative of one margin of the lesion; a more central portion of the lesion lies to the right where the patterns are different and less distinctive. A common theme of lesions in this Section is repeated; interconnected cords of squamous cells are supported by a widened papillary dermis. The lesion appears to sit upon the reticular dermis. There are scattered  keratin-filled cysts. The epithelial pattern is partially interrupted by delicate vascularized fibrous tissue. The pattern is such that this portion of the lesion might be characterized as an “irritated seborrheic keratosis.”


F2Ch20: The lesional epithelium shows hyperkeratosis, acanthosis, and papillomatosis. There are focal clusters of neutrophils in the keratin layer. Two patterns of squamous cell differentiation - a basal unit of germinative cells and a component of cells of superficial unit-like type - are represented.


F3Ch20: The epithelial pattern of closely spaced interconnected cords of squamous cells focally is interrupted in the area showing the expanse of delicate fibrous tissue. Some of the cords of cells project into the fibrous tissue; the cords have been interrupted in this area. There are scattered whorls of squamous cells.


F4Ch20: The pattern of an “irritated seborrheic keratosis” is represented on the right hand side of the field. To the left, nests of small basal cells extend from the hyperplastic epidermis into the widened papillary dermis. There are scattered infiltrates of lymphocytes in the papillary dermis. Some of the nests of basal cells are bulbous and expansile. In other areas, the cells form thin, interconnected cords.


F5Ch20: To the left, at the advancing deep margin, there is a transition from the population of squamous cells to a population of small, uniform basal cells. The pattern in the basal cell component is compatible with that of a well-differentiation basal cell carcinoma; the neighboring stroma is slightly activated.


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