Ch34aaP26aa Molluscum Contagiosum

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F1Ch34aa: A keratin-filled, epithelium-lined tube extends from the epidermis; it is attached to bulbous lobules. By location and configuration, these lobules seem to be altered sebaceous lobules. Molluscum inclusions first appear in cells that are 3 or 4 cell layers from the basement membrane. Prior to the appearance of the cytoplasmic inclusions, many of the squamous cells show peri-nuclear vacuoles. A similar component is partially represented at the right margin of the field. It is of interest that the layer of condensed keratin along the epithelium near the top of the field has a corrugated quality; this is a pattern that is of a type commonly emphasized in the diagnosis of a steatocystoma (F1Ch36; see also, F1Ch13).


F2Ch34aa: In this field, molluscum bodies are present in the superficial unit of the epidermis among granular cells; the bodies are well-formed. A blue arrow points to a body that has displaced the nucleus. This apparently is a superficial, tangential section of one of the follicle-like structures.


F3Ch34aa: Perinuclear vacuoles involve scattered cells, even at the level of the basal layer. This vacuolar change can be characterized as a form of ballooning degeneration. At this level, the inclusions appear to be honeycombed. The inclusions have a lavender tint.


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