Ch40bP32b Sebaceous Adenoma

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F1Ch40b (G7490): This is a continuation of the discussion of the sebaceous adenoma. Lavender germinative cells are admixed among intermediate cells. Mature and degenerating sebaceous cells are clustered to the left and above.


F2Ch40b: There is progressive differentiation from the germinative layer to mature sebaceous cells. Near the lumen of the sebaceous duct, the sebaceous cells degenerate and release the cytoplasmic lipids. The degenerating cells are either anuclear or show acidophilic, “ghost” nuclei. Keratinized debris has formed among the degenerating cells; the keratinized debris is brightly acidophilic.


F3Ch40b (H3032): This is a well developed sebaceous adenoma. The lobules are columnar in outline. Some of the lobules are attached to the epidermis. One keratin-filled lumen is represented. Germinative cells are basophilic. Sebaceous cells form scattered small clusters. The expansile tumor bulges at the surface of the skin. Neighboring follicles are distorted in collarette fashion.


F4Ch40b: Hyperplasia of germinative cells is a prominent feature. Multiple, small ductal components contain keratinized debris. The lesion is expansile; it is outlined by a band of condensed fibrous tissue.


F5Ch40b: The germinative cells have scanty, lavender cytoplasm and uniform, round nuclei. Mature sebaceous cells form scattered clusters. Some of the sebaceous cells are interspersed among squamous cells of the ductal components. In some of the ducts, keratinized debris is irregularly laminated; rounded defects among the lamellae are the size of sebaceous cells; the rounded defects are interpreted as lipid deposits that have been released from the cytoplasm of the degenerating sebaceous cells.


F6Ch40b: The keratinized debris is distorted by the interspersed lipid deposits. For some of the smaller ducts, keratinized debris is compactly condensed along the luminal surface; small heaps of keratinized debris along these surfaces produce a corrugated contour.


F8Ch40b: There is marked hyperplasia of germinative cells. Chromatin of the nuclei of the germinative cells is finely stippled and nucleoli are prominent. The patterns suggest that the peripheral rim of cytoplasm of the degenerating sebaceous cells contributes the thin layer of keratinized debris that confines the lipid deposits among the ductal cells.


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