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1. Histopathology of Inflammation

2. Minimal Deviation Melanoma, etc.

Navigation aids below this level have special attributes (as described both below, and in the Image Map)

F1Ch41b (R695) ( Continuation of Ch41a): To the far right, the clefts contain occasional fibrocytes. The large defect, just above the center of the field, appears to contain a faint mucinous matrix; a few flattened cells along the luminal surface may represent fibrocytes. To the left, many of the cells, with the characteristics of cells of a superficial unit, show perinuclear vacuoles; some of the vacuoles have compressed the nucleus.

F2Ch41b: Near the surface two whorls have evolved into keratin-filled lumens. The epithelium of the whorl blends with the superficial unit of the epidermis. In the lumen on the right, the keratinized lamellae are sharply defined and loosely aggregated. A granular layer is prominent and is confined to the domain of the whorl of cells. In the lumen on the left, cells, that retain the outline of their viable neighbors, have been sloughed; several of these cells show lavender cytoplasm with a loss of defined keratohyaline granules. Many of the sloughed, dead cells, away from the immediate area of the granular cells, retain their polygonal outlines, but show a loss of the lavender cytoplasmic staining. The keratinized debris is brightly acidophilic and compact. The pattern on the right is of a type that commonly is accepted as evidence of infundibular differentiation. Although the granular layer is prominent outlining the lumen on the left, the keratinized product more closely resembles that seen about the extremity of a clubbed hair shaft, as seen in catagen phenomena. At the bottom of the field , just to the right of a central vertical plane, a portion of a whorl is represented. About this whorl, there is a thin zone of mild cytolysis and dyskeratosis.

F3Ch41b: The pattern of keratinization is not characteristic of that seen in the differentiation of the superficial unit of the infundibular portion of a follicle. The patterns are as described in the caption for F2Ch41b. Cells of the granular layer first bulge into the lumen becoming somewhat rounded in outline. The cells then die and become a variation of a ghost cell; the ghost cells are polygonal and rather closely packed. The intensity of the lavender quality varies from cell to cell; this variability in staining qualities allows an observer to recognize the contribution of each cell to the aggregate of keratinized debris. At a more superficial level, the keratinized debris is compact and brightly acidophilic.