Ch7 Perivascular 
Adventitial Dermis

Buster (the plight of feral cats)

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F1Ch7 (106049): The level is approximately the mid-portion of the dermis. A vessel and its laminated adventitia runs diagonally across the field from right to left. Collagen bundles above are mostly cut in cross-section and somewhat hypereosinophilic. The domain above the vascular partition is the abnormal fibrous matrix of the reticular dermis as seen in some fibrous papules. Below the vascular partition, the collagen bundles are rather thin; they are loosely spaced in a clear matrix. Fibroblasts are hypertrophied; they have lavender cytoplasm. This partitioning of patterns is common in examples of fibrous papule. To the right, a vessel, cut in cross-section, is outlined by loosely spaced, brightly acidophilic lamellae. These lamellae are interpreted as reduplicated basement membranes.

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F2Ch7 (106049): A dilated vessel near the top of the field is cut in cross-section. There is a prominent degree of lamellar duplication of basement membrane. Small spindle cells are entrapped among the lamellae. The pattern of collagen bundles on the right differs somewhat from those on the left. On the left, the bundles are more uniform in size. On the right, some of the collagen are broad. On both sides, the complicated meshwork of fibers is an abnormal finding.

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F3Ch7 (106049): Dilated vessels that are represented in cross-sections show reduplication of basement membranes. The immediate sub-endothelial lamina is coarsened. To the right, vessels are clustered in angiomatoid patterns.

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F4Ch7 (106049): The duplication of basement membrane is more extensive on the superior margin of this vessel. The lamellae are thin and lightly stained. A pale, homogeneous matrix tends to obscure some of the lamina. This alteration in patterns is interpreted as a late change in the reduplicated lamina.

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F5Ch7 (1060489): The dermal-epidermal interface is represented. Two melanocytes are represented in the basal layer of the epidermis. An abnormal pattern of coarse collagen bundles extends to the dermal-epidermal interface; an adventitial stroma (papillary dermis) is not represented. The vessel on the left shows endothelial hyperplasia and reduplication of basement membrane. The lamina are pale; focally, they are somewhat obscured by a pale, pink matrix (blue arrows). On the right, the pale, homogeneous matrix is more extensive.

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 F6Ch7 (106049): Two vessels, that are cut in cross section, share a expanded adventitial domain. Lamina of basement membrane material are associated with a loose infiltrate of chronic inflammatory cells. Near the top of the field, a small vessel is outlined by a brightly acidophilic deposit in the pattern of an “exudative” lesion. One small lymphoid cell has a central, acidophilic nuclear body; this structure somewhat resembles a “Dutcher” body.

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